Physiologically relevant models for drug testing and barrier studies.
We offer fully validated iPSC-derived intestine and liver in-vitro models across increasing levels of biological complexity: from callable 2D transwell assays, to 3D organoids to dynamic Organ-on-Chip systems using the Emulate platform.
By applying our proprietary iPSC-derived cells in physiologically relevant culture formats, we provide human-based models that bridge the gap between conventional cell assays and complex tissue biology. This enables more predictive drug screening, toxicity testing, barrier function analysis and disease modelling, each model platform offering a step closer to the human in-vivo situation. We are also actively expanding our portfolio to include custom organoid-chip combinations for emerging research areas.
Differentiation, expansion, cryopreservation, and banking of stem/progenitor-stage small intestinal organoids.
Generation of mature epithelial linings for barrier, tolerance, and tissue-response studies.
Medium-throughput culture of up to 24 Intestine-on-Chips in parallel for up to 16 days.
TEER, FITC-Dextran permeability, villus-like fold morphology, and epithelial stress assessment.
Immunofluorescence, flow cytometry, bulk RNAseq, single-cell RNAseq, and bioinformatics.
Differentiation of iPSCs into fetal-like liver organoids and banking of progenitor-stage organoids.
Testing drug permeation, nutrient uptake, and barrier disruption in our validated Gut-on-Chip systems and transwell system.
Investigating the systemic interaction between intestinal health and liver metabolism in a connected dual-chip setup.
Realistic models of Inflammatory Bowel Disease (IBD), and infectious diseases using patient-specific iPSC lines.
Collaborative exploration of new organ models (e.g., Kidney, Lung, Brain) based on client research needs.
A step-by-step overview of our chip-based tissue model pipeline.
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We currently offer validated intestine and liver Organ-on-Chip models using the Emulate platform. Kidney, lung, and brain models are in active development.
Yes. We can culture your lines on our chip platform, or we can generate new patient-specific lines and differentiate them for your study.
Tell us about your project and we'll scope a solution for your lab.
